[HTML][HTML] The role of RNA splicing factors in cancer: regulation of viral and human gene expression in human papillomavirus-related cervical cancer

A Cerasuolo, L Buonaguro, FM Buonaguro… - Frontiers in cell and …, 2020 - frontiersin.org
… The spliceosome generates distinct mRNA isoforms by alternative usage of … The alternative
splicing of viral transcripts is also important to maximize the coding potential of the HPV16 …

[HTML][HTML] A master autoantigen-ome links alternative splicing, female predilection, and COVID-19 to autoimmune diseases

JY Wang, MW Roehrl, VB Roehrl, MH Roehrl - Journal of Translational …, 2022 - Elsevier
… , the coding genes of autoAgs predominantly contain multiple exons with many possible
alternative splicing variants, short transcripts, … While each cell type gives rise to a unique pool of …

The impact of RGS and other G-protein regulatory proteins on Gαi-mediated signaling in immunity

JH Kehrl - Biochemical pharmacology, 2016 - Elsevier
… express mRNA transcripts that encode 2 of the 5 Gβ subunits; … , which can bind type B ephrins,
an ATP/GTP-binding site, and … Alternative splicing creates multiple different isoforms of the …

[HTML][HTML] Humanization of Drosophila Gαo to Model GNAO1 Paediatric Encephalopathies

M Savitsky, GP Solis, M Kryuchkov, VL Katanaev - Biomedicines, 2020 - mdpi.com
… non-coding exon together with the first coding exon, which is subject to the alternative splicing.
… Then, we extracted total RNA from adult flies, and Gαo transcripts were examined through …

In-depth molecular profiling of an intronic GNAO1 mutant as the basis for personalized high-throughput drug screening

A Koval, YA Larasati, M Savitsky, GP Solis, JM Good… - Med, 2023 - cell.com
… We thus next investigated whether GTP binding and … 8G>A mutation creates an alternative
splicing acceptor site, … was performed on three different Gao-encoding plasmids used in this …

Transcriptomic Analysis Reveals That Rho GTPases Regulate Trap Development and Lifestyle Transition of the Nematode-Trapping Fungus Arthrobotrys oligospora

L Yang, X Li, N Bai, X Yang, KQ Zhang… - Microbiology …, 2022 - Am Soc Microbiol
… the transcript levels of several genes associated with protein … Here, we revealed that
alternative splicing events play a … IPR027417) and a small GTP-binding protein domain (IPR005225)…

[HTML][HTML] GNAO1 encephalopathy: further delineation of a severe neurodevelopmental syndrome affecting females

A Marcé-Grau, J Dalton, J López-Pisón… - Orphanet journal of rare …, 2016 - Springer
… *139311), encoding the alpha subunit of the heterotrimeric … is the alpha subunit of Go, a
member of the G-protein family, … is not involved in GDP/GTP binding so its mutation to proline is …

[HTML][HTML] Integrated transcriptomic and proteomic analyses uncover the early response mechanisms of Catharanthus roseus under ultraviolet-B radiation

Z Zhong, M Wu, T Yang, X Nan, S Zhang… - … of Photochemistry and …, 2024 - Elsevier
transcription factors family increased at both transcriptomic and proteomic levels. At the same
time, the numbers of differential alternative splicing … of genes encoding different enzymes in …

Compendium of proteins containing segments that exhibit zero‐tolerance to amino acid variation in humans

AL Sanders, JN Hermanson, DC Samuels… - Protein …, 2022 - Wiley Online Library
… segments in a given protein-encoding transcript found in the … One important finding is that
proteins involved in RNA splicing … factor 1 GTP binding protein involved in protein trafficking. …

Crosstalk between alternative splicing and inflammatory bowel disease: Basic mechanisms, biotechnological progresses and future perspectives

C Zou, X Zan, Z Jia, L Zheng, Y Gu, F Liu… - Clinical and …, 2023 - Wiley Online Library
… are two Kindlin-1 transcripts (5.8 and 4.9 kb) in murine and human colon, which can
correspondingly encode the 43 kDa kindlin-1 and full-length 74 kDa protein … Tu GTP binding